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Test Code ABPA Allergic Bronchopulmonary Aspergillosis Panel I

Clinical Indications

ABPA is a hypersensitivity disease of the lungs caused by
Aspergillus fumigatus. It is an important complication for patients
with asthma and cystic fibrosis. Diagnosis involves clinical,
immunologic and radiographic criteria and no single test is
sufficiently discriminating. ABPA is under-diagnosed: prospective
studies indicate that 7 to 14 % of patients with
corticosteroid-dependent asthma meet the generally accepted
definitions as to 6% of patients with cystic fibrosis. Individuals
with the HLA DR2 and HLA DR5 haplotypes appear to be predisposed to
ABPA.

Additional Test Codes

Epic Order Name: ASPERGILLOSIS PANEL (aka ABPA)
Sunquest Order Code: ABPA
Epic Px Code: LAB2028

Specimen Collection Type

Preferred: Gold
Acceptable: Red

Minimum Collection Volume

1.5 mL

Reference Range

Total
IgE

Age

Reference
Range

1 – 11 months

0 – 12

1 year

0 – 15

2 year

1 – 29

3 year

4 – 35

4 year

2 – 33

5 year

8 – 56

6 year

3 – 95

7 year

2 – 88

8 year

5 – 71

9 year

3 – 88

10 year

7 – 110

11 – 14 year

7 – 111

15 – 19 year

6 – 96

20 – 30 year

4 – 59

31 – 50 year

5 – 79

51 – 80 year

3 – 48

 

Aspergillus
fumigatus IgE

ImmunoCAP®
Quantitative Scoring Guide:

Class

IgE
(kU/L)

Comment

0

<0.10

Negative

0/1

0.10-0.34

Equivocal/Borderline

1

0.35-0.69

Low Positive

2

0.70-3.49

Moderate
Positive

3

3.50-17.49

High Positive

4

17.50-49.99

Very High
Positive

5

50.00-99.99

Very High
Positive

6

>99.99

Very High
Positive

Note that Viracor
Eurofins includes an extra calibrator at 0.10 kU/L and uses it
to
define an optional equivocal class.

 

Aspergillus
fumigatus IgG

The units are
micrograms/mL of specific IgG. The reference varies by
allergen.


 

mcg/mL of
IgG

Lower Limit of
Quantitation

2.0

Upper Limit of
Quantitation

200

Reference
ranges vary by allergen.

Critical Value

N/A

Interpretation

N/A

Rejection Criteria

Lipemic samples may lead to rejection.

Specimen Availability for Add-on Testing

2 Days

Specimen Stability

Refrigerated (preferred): 8 days
Ambient: 2 hours
Frozen: greater than 1 month

Day(s) Performed

Varies

Performing Lab- Department

TUKHS-BH-Mail Outs

CPT Code

82785, 86001, 86003

Test Alias

Tests in this Panel:
Total IgE
Aspergillus fumigatus IgE
Aspergillus fumigatus IgG

Additional Information / Notes

Turnaround time: 2-4 business days from receipt of specimen