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HelpTest Code AGSER Aspergillus Galactomannan EIA (Serum)
Clinical Indications
The Platelia™ Aspergillus Galactomannan EIA is a test,
when used in conjunction with other diagnostic procedures, such
as
microbiological culture, histological examination of biopsy
specimens, and radiographic evidence that can be used to aid in
the
diagnosis of Invasive Aspergillosis. Twice weekly monitoring of
neutropenic patients is often recommended in the peer-reviewed
literature to obtain maximum diagnostic utility of the assay.
Additional Test Codes
Epic Order Name: ASPERGILLUS
(GALACTOMANNAN) AG (aka AGSER)
Sunquest Order Code: AGSER
Epic Px Code: LAB2081
Specimen Collection Type
Preferred: Gold
(cannot be shared with other tests)
Minimum Collection Volume
1.0 mL
Reference Range
The reference range is an index of <0.5 numerical index
values will be reported.
Patients with an index of ≥0.5 are considered to be
positive
for galactomannan antigen.
Patients with an index of <0.5 are considered to be negative
for
galactomannan antigen.
Specimens testing positive will be retested to confirm the
positive
result.
•A reference Index Value of <0.5 has been shown to be
appropriate for both serum and bronchial lavage specimen types.
Critical Value
N/A
Interpretation
For maximum sensitivity, the test should be performed at
least
twice weekly during neutropenia. The exact frequency of testing
in
non-hospitalized patients with chronic
graft-versus-host-disease
(CGVHD) would depend upon the degree of
immunosuppression. The test
should be used in conjunction with other diagnostic procedures.
Two consecutive positive results are required for classification
as
true positive, thus it is recommended that a follow-up specimen
be
submitted from the patient upon receipt of the initial positive
result; ideally prior to initiation of anti fungal therapy to
achieve maximum specificity.
Rejection Criteria
Specimens that have been poured off (due to the potential
for
environmental contamination of the sample that can lead to
false
positive results, the gold top tubes should be centrifuged and
sent
to the lab with the cap intact). Lipemic, icteric, or
hemolyzed specimens, specimens that have been stored at ambient
temperature, specimens received in trap containers, specimens
beyond their acceptable length of time from collection as listed
in
the Specimen Stability.
Specimen Availability for Add-on Testing
This test cannot be added on.
Specimen Stability
Frozen (preferred): 14 days
Refrigerated: 5 days
Ambient: Unacceptable
Day(s) Performed
Monday through Saturday
Performing Lab- Department
TUKHS-BH-Mail Outs
CPT Code
87305
LOINC Code
44357-2
Test Alias
Platelia Aspergillus Galactomannan EIA (Serum)
Additional Information / Notes
To avoid potential contamination, we send the original tube,
centrifuged but not aliquotted. Therefore this tube cannot be
shared with other tests.
Assay Limitations
A negative test result cannot rule out the diagnosis of
Invasive
Aspergillosis. Patients at risk for Invasive Aspergillosis
should
be tested twice per week.
If a positive result is obtained, a second specimen should be
collected and sent for testing immediately.
The performance of the test has not been evaluated with
neonatal
specimens.
This test may exhibit reduced detection in patients with
chronic
granulomatous disease and Job’s Syndrome.
The concomitant use of mold-active, anti fungal therapy in some
patients with Invasive Aspergillosis may result in reduced
sensitivity of the test.
There are reports in the literature of positive galactomannan
test
results in patients receiving
piperacillin/tazobactam,therefore,
results in these patients should be interpreted with caution
and
confirmed with other diagnostic methods.
There are reports in the literature of positive galactomannan
test
results in patients with intestinal mucositis caused by
chemotherapy and irradiation, which allows for extra absorption
of
dietary galactomannan.
False-positive Galactomannan results have been shown in
patients
receiving Plasmalyte for intravenous hydration or if Plasmalyte
is
used for BAL collection.