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Test Code ALA24 Aminolevulinic Acid (ALA), 24 Hour Urine

Clinical Indications

Evaluate suspected aminolevulinic acid dehydratase deficiency (ADP) porphyria or hereditary tyrosinemia.

Additional Test Codes

Epic Order Name: AMINOLEVULINIC ACID (ALA) 24 HR URINE (aka ALA24)
Sunquest Order Code: ALA24
Epic Px Code: LAB6323

Specimen Collection Type

24-hour urine (no preservative). Refrigerate 24-hour specimens during collection.

Minimum Collection Volume

1.2 mL

Reference Range

Components

Reference Interval

Aminolevulinic Acid - per volume

0-35 µmol/L

Aminolevulinic Acid - per 24h

0-60 µmol/d

Creatinine, Urine - per 24h

Age

Male

Female

3-8 years

140-700 mg/d

140-700 mg/d

9-12 years

300-1300 mg/d

300-1300 mg/d

13-17 years

500-2300 mg/d

400-1600 mg/d

18-50 years

1000-2500 mg/d

700-1600 mg/d

51-80 years

800-2100 mg/d

500-1400 mg/d

81 years and older

600-2000 mg/d

400-1300 mg/d

Critical Value

N/A

Interpretation

Increased ALA concentration is associated with exposure to alcohol, lead, and a variety of other agents. Massive elevation of ALA occurs in the acute porphyrias and hereditary tyrosinemia.

Rejection Criteria

Body fluids other than urine.

Specimen Availability for Add-on Testing

1 day

Specimen Stability

Frozen (preferred): 1 month
Refrigerated: 4 days
Ambient: Unacceptable

Day(s) Performed

Mon, Wed, Fri

Performing Lab - Department

TUKHS-BH-Mail Outs

CPT Code

82135

LOINC Code

N/A

Test Alias

5-Aminolevulinic Acid
ALA
Delta-ALA
Delta-Aminolevulinic Acid

Additional Information / Notes

Specimen preservation with acid or base is discouraged and may cause assay interference. When collecting urine for additional tests that require acid or base preservation, the ALA aliquot should be removed prior to the addition of the acid or base.