Sign in →

Test Code APC Gastric Parietal Cell Antibody, IgG

Clinical Indications

0050596

Additional Test Codes

Epic Order Name: ANTI-PARIETAL CELL ANTIBODY
Sunquest Order Code: APC
Epic Px Code: LAB2069

Specimen Collection Type

Preferred: Gold
Acceptable: Red

Minimum Collection Volume

0.25 mL serum

Reference Range

Copy and paste table from: http://ltd.aruplab.com/Tests/Pub/0050596

Critical Value

N/A

Interpretation

In the context of vitamin B12 deficiency, the presence of gastric parietal cell antibodies (PCA) and/or intrinsic factor antibodies in association with macrocytic anemia is considered diagnostic for pernicious anemia (PA). However, the presence of gastric PCAs alone is not specific for PA. Gastric PCAs may occur with increased frequency in unaffected family members, a small percentage of healthy individuals, and patients with other autoimmune diseases, such as autoimmune thyroiditis.

Rejection Criteria

Urine or plasma. Contaminated, heat-inactivated, grossly hemolyzed, or severely lipemic specimens.

Specimen Availability for Add-on Testing

2 days

Specimen Stability

Refrigerated (preferred): 2 weeks
Ambient: 48 hours
Frozen: 1 year

Day(s) Performed

Mon, Wed-Sat

Performing Lab - Department

TUKHS-BH-Mail Outs

CPT Code

83516

LOINC Code

40960-7

Test Alias

Anti-GPA (AGPA)
Anti-Parietal Cell Antibody (APCA)
Hydrogen Potassium (H+/K+) ATPase
Parietal Cell Ab, IgG
PCA
PCA IgG

Additional Information / Notes

Most patients with pernicious anemia have parietal cell antibodies. However, the fact that such antibodies are found with increased frequency in unaffected family members, as well as in patients with other autoimmune diseases, suggests these antibodies do not cause disease by themselves.