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Test Code ASM Anti-Smooth Muscle AB

Clinical Indications

Test Method: Immunofluorescence Assay (IFA)

High titers of anti-smooth muscle (ASM) antibodies are often detected in patients with auto-immune chronic active hepatitis and lower titers may occur with viral infections and malignancies.

Additional Test Codes

Epic Order Code: Anti-Smooth Muscle AB
Sunquest Order Code: ASM
Px Order Code: LAB2074

Specimen Collection Type

Serum
Preferred: Gold top (SST gel separator)
Acceptable: Red top (serum tube)

Allow blood to clot at room temp (18-24°C). Serum should be separated from the clot ASAP to minimize hemolysis.

Minimum Collection Volume

0.3 mL

Reference Range

<20

Critical Value

N/A

Interpretation

Negative: <1:20
Positive: >1:20

ASM titer is performed from 1:20 to 1:1280 dilutions.

Antibody titers >1:80 occur commonly in patient with autoimmune hepatitis. Lower titers (usually <1:80) may occur in patient with chronic viral hepatitis and malignancies.

A negative result does not exclude a diagnosis of autoimmune hepatitis.

Rejection Criteria

Gross hemolysis
Gross lipemia

Specimen Availability for Add-on Testing

3 days

Specimen Stability

7 days at 2-8°C
14 days at -20°C

Day(s) Performed

Monday through Friday

Performing Lab- Department

TUKHS-BH-Microbiology

CPT Code

86255

LOINC Code

14252-1

Test Alias

N/A

Additional Information / Notes

N/A