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Test Code COPFR Copper, Free, Serum or Plasma

Clinical Indications

May be useful in the assessment of copper overload or response to copper-reducing therapies. Directly measures the free (non-ceruloplasmin bound) fraction of copper.

Additional Test Codes

Epic Order Name: COPPER FREE SERUM OR PLASMA (aka COPFR)
Sunquest Order Code: COPFR
Epic Px Code: LAB2161

Specimen Collection Type

Royal blue (no additive) serum

Royal blue (EDTA) plasma

Minimum Collection Volume

1.5 mL

Reference Range

Unit:  mcg/L

Reporting Limit:  11 mcg/L

NMS Labs derived data:

Median, 1.2 mcg/L; range, Less than 1 - 180 mcg/L

(N = 937).

10 - 90% of concentrations range from less than 1 - 54 mcg/L

NOTE:  results below the reporting limit of 11 mcg/L will be reported as "None Detected."

Critical Value

n/a

Rejection Criteria

Specimens collected in or poured off into non-trace element-free (metal-free) tubes or tubes containing gel. Specimens that are not separated from the red cells or clot.

Specimen Availability for Add-on Testing

2 Days

Specimen Stability

Refrigerated (preferred): 1 month
Ambient: 1 month
Frozen: 1 month

Day(s) Performed

Varies

Performing Lab - Department

TUKHS-BH-Mail Outs

CPT Code

82525

LOINC Code

5631-7

Test Alias

Copper Index
Cu
Cu, Plasma
CuFree
Free copper
Non-Ceruloplasmin Bound Copper
Unbound Copper

Additional Information / Notes

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).