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Test Code CRGSP Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma

Important Note

STOP!

Please see the specimen requirements field below before proceeding. Special draw instructions included

Additional Codes

Epic Order Name: CRYOGLOB AND CRYOFIBRINO PANEL W REFLEX IMMUNOFIXATION
Sunquest Order Code: CRGSP
Epic Px Code: LAB3042

Reporting Name

Cryo Panel, S and P

Useful For

Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases

 

Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

 

This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRY_S Cryoglobulin, S Yes Yes
CRY_P Cryofibrinogen, P No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a positive result after 1 or 7 days, then immunofixation will be performed at an additional charge. Positive cryoglobulins of 0.1 mL or above of precipitate will be typed once.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma EDTA
Serum Red


Specimen Required


Both plasma and serum are required.

 

Cryofibrinogen

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of plasma from red blood cells.

3. Place plasma into an appropriately labeled plastic vial.

 

Cryoglobulin

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of serum from red blood cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require collection and submission a new specimen.


Laboratory Services Directory Note:
  1. Collect blood in 3 red-top tubes and 1 lavender tube pre-warmed to body temperature (tubes must remain at 37 degrees C!).
  2. It is best to wrap the tubes with activated heel-warmers both before and after they are collected.
  3. Fill tubes with as much blood as the vacuum will draw.  Note that soft-draw (light purple)  lavender-tops will only fill half-way.
  4. Gold-top and pearl-top (gel) tubes are NOT acceptable!
  5. The red-top and lavender tubes must be wrapped in a heel warmer and sent to the lab IMMEDIATELY!

Specimen Minimum Volume

Plasma: 0.5 mL
Serum: 3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Refrigerated (preferred)
  Frozen 
Serum Red Refrigerated (preferred)
  Frozen 

Reference Values

CRYOGLOBULIN

Negative (positives reported as percent or trace amount)

If positive after 1 or 7 days, immunotyping of the cryoprecipitate is performed at an additional charge.

 

CRYOFIBRINOGEN

Negative

Quantitation and immunotyping will not be performed on positive cryofibrinogen.

Day(s) Performed

Monday through Friday

CPT Code Information

82585

82595

86334-Immunofixation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRGSP Cryo Panel, S and P 74352-6

 

Result ID Test Result Name Result LOINC Value
2685 Cryofibrinogen, P 11043-7
2684 Cryoglobulin, S 12201-0

Report Available

2 to 10 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

CRY_S, CRY_P: Quantitation and Qualitative Typing Precipitation

IMFXC: Immunofixation

Forms

If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.

Secondary ID

83659

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.