Additional Information / Notes

Detects somatic small nucleotide variations (SNVs) and small insertions/deletions (INDELs) in 275 genes of importance across various types of cancers, including but not limited to breast cancers, lung cancers, colorectal cancers, and melanomas, as well as various hematologic neoplasms. The presence of gene variants in various cancers can serve as a prognostic indicator and can impact a patient’s response to some anti-cancer therapies, making detection of gene variants useful in guiding treatment decisions.

Genes Tested: ABL1, ADA, ANKRD26, ASXL1, ASXL2, ATM, ATRX, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BRAF, BRCA1, BRCA2, BRINP3, C17orf97, CALR, CARD11, CBL, CBLB, CBLC, CDKN2A, CEBPA, CHEK2, CREBBP, CRLF2, CSF1R, CSF3R, CTCF, CUX1, DAXX, DDX41, DNM2, DNMT1, DNMT3A, EED, EGFR, ELANE, EP300, ETNK1, ETV6, EZH2, FAM154B, FAM47A, FAS, FBXW7, FLRT2, FLT3, GATA1, GATA2, GJB3, GNAS, HNRNPK, HRAS, IDH1, IDH2, IKZF1, IKZF3, IL7R, JAK1, JAK2, JAK3, KAT6A, KCNA4, KCNK13, KDM6A, KDR, KIT, KLHDC8B, KLHL6, KMT2A, KMT2C, KRAS, LRRC4, LUC7L2, MAP2K1, MLH1, MPL, MSH2, MSH6, MYC, MYD88, NBN, NF1, NOTCH1, NPAT, NPM1, NRAS, NSD1, NTRK3, OR13H1,OR8B12, P2RY2, PAX5, PCDHB1, PDGFRA, PHF6, PML, PMS2, PRAMEF2, PRF1, PRPF40B, PRPF8, PTEN, PTPN11, RAD21, RB1, RELN, RUNX1, SETBP1, SF1, SF3A1, SF3B1, SH2B3, SH2D1A, SMARCB1, SMC1A, SMC3, SRP72, SRSF2, STAG2, STAT3, STXBP2, SUZ12, TAL1, TERC, TERT, TET2, TNFRSF13B, TP53, TPMT, TUBA3C, U2AF1, U2AF2, WAS, WRN, WT1, XPO1, ZRSR2.