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HelpTest Code HHV6C HHV-6 Quantitative Real-time PCR (CSF)
Clinical Indications
Quantitative HHV-6 DNA PCR can be used for
early detection of a primary infection, for tracking the course
of
infection, and for monitoring response to treatment.
Quantitative
HHV-6
DNA
PCR does not
differentiate HHV-6 viremia from patients with
chromosomally
integrated HHV-6, a relatively uncommon
congenital occurrence that has not been conclusively related to
a
disease state. Treatment of HHV-6 in
immunocompromised patients presents challenges, including drug
toxicity, delayed onset of disease after discontinuing therapy,
and
emergence of mutations that may affect the ability of
diagnostic
assays to detect them efficiently.
Additional Test Codes
Epic Order Name: HUMAN HERPES VIRUS 6 QUANT PCR CSF (aka HHV6C)
Sunquest Order Code: HHV6C
Epic Px Code: LAB7093
Specimen Collection Type
CSF
Minimum Collection Volume
0.5 mL
Reference Range
81 copies/mL to 1×10^8 copies/mL
Critical Value
N/A
Interpretation
Detects both Type A and Type B in one assay. The primers and
probes used in this assay are specific for known strains of
HHV-6 based on
similarity search
algorithms. Additionally, no cross reactivity was detected when
tested against adenoviruses, BKV,
CMV,
EBV,
HSV-1,
HSV-2,
HHV-7,
HHV-8,
JCV, parvovirus
B19, SV-40, and
VZV.
Rejection Criteria
Specimens beyond their acceptable length of time from
collection
as listed in the specimen stability, specimens other than
cerebrospinal fluid (CSF)
Specimen Availability for Add-on Testing
This test cannot be added on (Critical frozen)
Specimen Stability
Frozen: 7 days
Refrigerated: Unacceptable
Ambient: Unacceptable
Day(s) Performed
Monday through Saturday
Performing Lab- Department
TUKHS-BH-Mail Outs
CPT Code
87533
LOINC Code
N/A
Test Alias
Herpes Virus-6 PCR, CSF
Herpesvirus 6 PCR, CSF
HHV-6
DNA
Quant, CSF
Human Herpes Virus-6 PCR, CSF
Additional Information / Notes
Turnaround time: Same day (within 8 – 12 hours from
receipt of specimen)