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HelpTest Code HIVD HIV 1/2 Antibody Differentiation
Clinical Indications
The Geenius HIV-1/2 antibody differentiation is used to confirm the presence of HIV-1 and/or HIV-2 antibodies in specimens reactive by the HIV-1/2 antibody and antigen screen (4th generation). The assay may also be used to confirm the presence of HIV-1 and/or HIV-2 antibodies in pediatric subjects ( ≥ 2 years).
Additional Test Codes
Epic Order Name: HIV-1/HIV-2 Antibody Differentiation
Sunquest Order Code: HIVD
Epic Px Code: LAB3180
Specimen Collection Type
Pearl, SST
Minimum Collection Volume
0.5 mL plasma or serum
Reference Range
HIV-1 and HIV-2 nonreactive
Critical Value
N/A
Interpretation
| HIV-1 Result | HIV-2 Result | Serological Interpretation Comment |
|---|---|---|
| Nonreactive | Nonreactive | Indeterminate. The specimen is reactive by initial screen and non-reactive for HIV antibodies by differentiation assay. HIV nucleic acid testing (HIV-1 quant PCR; HIVUS) is recommended. A new specimen and order are required. |
| Indeterminate | Nonreactive | Indeterminate. The specimen is reactive by initial screen and indeterminate for HIV-1 antibodies by differentiation assay. HIV nucleic acid testing (HIV-1 quant PCR: HIVUS) is recommended. A new specimen and order are required. |
| Nonreactive | Indeterminate | Indeterminate. The specimen is reactive by initial screen and indeterminate for HIV-2 antibodies by differentiation assay. HIV-2 nucleic acid testing is recommended. A new specimen and order are required. |
| Indeterminate | Indeterminate | Indeterminate. The specimen is reactive by initial screen and indeterminate for HIV antibodies by differentiation assay. HIV nucleic acid testing (HIV-1 quant PCR; HIVUS) is recommended. A new specimen and order are required. |
| Reactive | Nonreactive | HIV-1 infection. HIV nucleic acid testing (HIV-1 quant PCR; HIVUS) is recommended. A new specimen and order are required. |
| Reactive | Indeterminate | HIV-1 infection. HIV-2 indeterminate result is likely due to cross-reactivity of HIV-1 antibodies on HIV-2 antigens and confirmation of HIV-2 is not required. HIV nucleic acid testing (HIV-1 quant PCR; HIVUS) is recommended. A new specimen and order are required. |
| Nonreactive | Reactive | HIV-2 infection. HIV-2 nucleic acid testing is recommended. A new specimen and order are required. |
| Indeterminate | Reactive | HIV-2 infection. HIV-1 indeterminate result is likely due to cross-reactivity of HIV-2 antibodies on HIV-1 antigens and confirmation of HIV-1 is not required. HIV-2 nucleic acid testing is recommended. A new specimen and order are required. |
Rejection Criteria
Specimens outside of stability.
Specimens which do not comply with TUKHS Lab’s specimen requirements.
Specimen Availability for Add-on Testing
This test cannot be added on.
Specimen Stability
Prior to centrifugation: 48 hours at 18-30°C, 3 days at 2-8°C
After centrifugation: 48 hours at 18-30°C, 7 days at 2-8°C
Day(s) Performed
Daily, Monday through Sunday
Performing Lab - Department
TUKHS-BH-MOLECULAR MICROBIOLOGY
CPT Code
86701 and 86702
LOINC Code
HIV1AB: 68961-2
HIV2AB: 81641-3
HIVABI: 80203-3
Test Alias
Anti-HIV-1/2
HIV Antibody Differentiation
HIV Types 1 and 2 Antibodies
HIV-1/2 Ab
HIV-1/2 Antibody Differentiation
Additional Information / Notes
N/A