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Test Code MSNGS Melanoma 3 Gene NGS Panel (KIT, NRAS, BRAF)

Clinical Indications

N/A

Additional Test Codes

Epic Order Name: MELANOMA SMALL NGS PANEL 3 GENES
Sunquest Order Code: MSNGS
Epic Px Code: LAB8201

Specimen Collection Type

FFPE tissue: 5 to 10 slides, each up to 10 ?m thick plus one additional H&E reference slide with tumor tissue marked.

Minimum Collection Volume

FFPE: 5 unstained slides + 1 representative H&E

Additional Information / Notes

Detects somatic small nucleotide variations (SNVs) and small insertions/deletions (INDELs) in BRAF, KIT and NRAS. Up to 70 % of all melanomas harbor a recurrent “driver” mutation in BRAF, KIT and/or NRAS; the particular mutations present in melanomas, in addition to clinical features, are used for molecular subtyping of these tumors and provide important information about prognosis, diagnosis, and potential efficacy of targeted therapies. The presence of a mutation in one of these genes can predict response to tyrosine kinase inhibitor (TKI) therapies.

Reference Range

An interpretive report will be provided

Critical Value

N/A

Interpretation

An interpretive report will be provided

Rejection Criteria

FFPE tumor specimen with a tumor percentage < 5 %, or with otherwise inadequate cellular content.

Specimen Availability for Add-on Testing

Only for additional CMOL testing; additional sample may be required, see test sample requirements and stability.

Specimen Stability

FFPE: n/a.

Day(s) Performed

9:00 AM – 5:00 PM, Monday through Friday; varies

Performing Lab - Department

Clinical Molecular Oncology Laboratory

CPT Code

BRAF (81210), KIT (81272, 81273), NRAS (81311, 81403)

LOINC Code

N/A

Test Alias

N/A