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Test Code NGS50M Myeloid 50 Gene NGS Panel Non Blood

Additional Test Codes

Epic Order Name: Myeloid 50 Gene NGS Panel Non Blood
Sunquest Order Code: NGS50M
Px Order Code: LAB8249

Specimen Collection Type

Bone Marrow Aspirate: EDTA (lavender-top) tube, 3.0 mL;
FFPE tissue: 5 to 10 slides, each 10 micron thick plus one additional H&E reference slide with tumor tissue marked.

For peripheral blood see: Myeloid 50 Gene NGS Panel Blood (NGS50L)

Minimum Collection Volume

Bone Marrow Aspirate: minimum 0.5 mL;
FFPE: minimum 5 unstained slides

Additional Information / Notes

Genes Tested: ABL1, ANKRD26, ASXL1, BCR, BLM, BRAF, CALR, CBL, CEBPA, CSF3R, CUX1, DDX41, DNMT3A, ELANE, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA2, IDH1, IDH2, IKZF1, JAK2, KIT, KRAS, MPL, MYD88, NF1, NOTCH1, NPM1, NRAS, PAX5, PDGFRA, PTPN11, RUNX1, SETBP1, SF3B1, SH2B3, SRP72, SRSF2, STAG2, STAT3, TERC, TERT, TET2, TP53, U2AF1, WT1, ZRSR2.

Reference Range

An interpretive report will be provided

Critical Value

N/A

Specimen Availability for Add-on Testing

Only for additional testing provided by CMOL; additional sample may be required, see individual test sample requirements and stability.

Specimen Stability

Bone Marrow Aspirate: 5 days at 4°C;
FFPE: N/A

Day(s) Performed

8:30 AM – 5:00 PM, Monday through Friday; varies

Performing Lab - Department

TUKHS – Molecular Pathology (CMOL)

CPT Code

81479

LOINC Code

N/A

Performing Lab- Department

TUKHS Molecular Pathology (CMOL)

Clinical Indications

Detects somatic small nucleotide variations (SNVs) and small insertions/deletions (INDELs) in 50 genes of importance across various types of hematologic malignancies. Useful for diagnosis support, prognosis, risk stratification,
and informing possible treatment decisions and clinical trials. The presence of gene variants in various cancers can serve as a prognostic indicator and can impact a patient’s response to some anti-cancer therapies, making detection
of gene variants useful in guiding treatment decisions.

Test Alias

N/A

Rejection Criteria

FFPE: Decalcified specimen;
Bone Marrow Aspirate: Severely clotted or hemolyzed samples