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Test Code NOTCH1 NOTCH1 - Next-Generation Sequencing, Non Blood

Clinical Indications

N/A

Additional Test Codes

Epic Order Name: NOTCH1 NON-BLOOD
Sunquest Order Code: NOTCH1
Epic Px Code: LAB8148

Specimen Collection Type

Bone Marrow Aspirate: EDTA (lavender-top) tube, 3.0 mL (Minimum 0.5 mL);
FFPE tissue: 5 to 10 slides, each up to 10 ?m thick plus one additional H&E reference slide with tumor tissue marked.

Minimum Collection Volume

Bone Marrow Aspirate: 0.5 ml;
FFPE: 5 unstained slides + 1 representative H&E

Additional Information / Notes

Useful in chronic lymphocytic leukemia (CLL) and small lymphocytic lymphomas (SLL). Helps predict prognosis, progression to Richter’s syndrome, time to first treatment, and overall survival.

Reference Range

An interpretive report will be provided

Critical Value

N/A

Interpretation

An interpretive report will be provided

Rejection Criteria

Frozen, severely hemolyzed, or clotten specimen. FFPE tumor specimen with a tumor percentage < 5 %, or with otherwise inadequate cellular content.

Specimen Availability for Add-on Testing

Only for additional CMOL testing; additional sample may be required, see test sample requirements and stability.

Specimen Stability

Bone Marrow Aspirate: 96 hrs at 4°C;
FFPE: n/a.

Day(s) Performed

9:00 AM – 5:00 PM, Monday through Friday; varies

Performing Lab - Department

Clinical Molecular Oncology Laboratory

CPT Code

81407

LOINC Code

N/A

Test Alias

N/A