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Test Code NRASN NRAS - Next-Generation Sequencing, Exons 2, 3 and 4

Clinical Indications

N/A

Additional Test Codes

Epic Order Name: NRAS NGS EXONS 2, 3 & 4
Sunquest Order Code: NRASN
Epic Px Code: LAB8175

Specimen Collection Type

FFPE tissue: 5 to 10 slides, each up to 10 ?m thick plus one additional H&E reference slide with tumor tissue marked.

Minimum Collection Volume

FFPE: 5 unstained slides + 1 representative H&E

Additional Information / Notes

Useful for lung cancers, colorectal cancers, and melanomas for predicting potential resistance to TKI therapies. The presence of NRAS variants in exons 2, 3, and/or 4 is associated with lack of response to tyrosine-kinase inhibitors (TKIs).

Reference Range

An interpretive report will be provided

Critical Value

N/A

Interpretation

An interpretive report will be provided

Rejection Criteria

FFPE tumor specimen with a tumor percentage < 5 %, or with otherwise inadequate cellular content.

Specimen Availability for Add-on Testing

Only for additional CMOL testing; additional sample may be required, see test sample requirements and stability.

Specimen Stability

FFPE: n/a.

Day(s) Performed

9:00 AM – 5:00 PM, Monday through Friday; varies

Performing Lab - Department

Clinical Molecular Oncology Laboratory

CPT Code

81311 (exon 2, exon 3), 81403 (exon 4)

LOINC Code

N/A

Test Alias

N/A