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Test Code P2Y12 Verify Now PRU

Important Note

Special Collection Tubes required.

Call 913-588-1730 for collection tubes and instructions.Test must be collected at TUKHS Main Campus due stability of platelets.

Clinical Indications

Laboratory monitoring of antiplatelet therapy with P2Y12
inhibitor drugs, including clopidogrel (Plavix), prasugel
(Effient), and ticagrelor (Brilinta), and cangrelor (Kengreal).

Clinical indications for testing include:
1. Documenting patient adherence to drug therapy.
2. Confirming suspected drug resistance in patients with ischemic
events.
3. Determining the optimal time of invasive procedures after
discontinuing the drug.

Additional Test Codes

Epic Order Name: PLATELET P2Y12 RESPONSE (AKA P2Y12)
Sunquest Order Code: P2Y12
Px Order Code: LAB3116

Specimen Collection Type

Call lab at 913-588-1730 for special tubes
White Top Tubes

Minimum Collection Volume

2mL

Reference Range

180-335 PRU (P2Y12 Reaction Units)

Critical Value

N/A

Interpretation

Value less than 180 PRU is evidence of a P2Y12 inhibitor drug
effect.

Rejection Criteria

Clotted

Specimen Availability for Add-on Testing

4 hours

Specimen Stability

4 Hours

Day(s) Performed

Monday through Sunday

Performing Lab - Department

TUKHS-BH-Hematology

CPT Code

85576

LOINC Code

N/A

Test Alias

N/A

Additional Information / Notes

1. The best time to run the test:

Plavix- 7 days on 75 mg maintenance dose, 8 hours after 300 mg
bolus dose, 6 hours after 600 mg bolus dose.

Effient- 5 days on 5 mg or 10 mg maintenance dose, 45 minutes
after 60 mg bolus dose.

Brilinta- 1 day on 60 mg or 90 mg maintenance dose but within 8
hours of last dose, between 2 hours and 8 hours after 180 mg bolus
dose.

2. Glycoprotein IIb/IIIa inhibitor drugs – patients who
have been treated with glycoprotein IIb/IIIa inhibitor drugs should
not be tested with the VerifyNow PRUTest until platelet
glycoprotein IIb/IIIa function has recovered. The recovery period
after the drug is discontinued is 14 days for abciximab (ReoPro),
and 48 hours for eptifibatide (Integrillin) and tirofiban
(Aggrastat).

3. Inherited platelet function disorders – patients with
von Willebrand disease, Glanzmann thrombasthenia, and
Bernard-Soulier syndrome should not be tested with the VerifyNow
PRUTest.