Sign in →

Test Code PMSCLN PM/Scl-100 Antibody, IgG by Immunoblot

Clinical Indications

May be useful when evaluating for systemic sclerosis or connective tissue disease associated with overlapping features of systemic sclerosis and/or myositis.

Additional Test Codes

Epic Order Name: PM/SCL 100 AB, IGG
Sunquest Order Code: PMSCLN
Epic Px Code: LAB3008

Specimen Collection Type

Preferred: Gold
Acceptable: Red

Minimum Collection Volume

0.3 mL

Reference Range

Negative

Critical Value

N/A

Interpretation

The presence of PM/Scl-100 IgG antibody along with a positive ANA IFA nucleolar pattern is associated with connective tissue diseases such as polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), and polymyositis/systemic sclerosis overlap syndrome. The clinical relevance of PM/Scl-100 IgG antibody with a negative ANA IFA nucleolar pattern is unknown. PM/Scl-100 is the main target epitope of the PM/Scl complex, although antibodies to other targets not detected by this assay may occur.

Rejection Criteria

Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Specimen Availability for Add-on Testing

2 Days

Specimen Stability

Refrigerated (preferred): 2 weeks
Ambient: 48 hours
Frozen: 1 year

Day(s) Performed

Tue, Thu, Sat

Performing Lab- Department

TUKHS-BH-Mail Outs

CPT Code

86235

LOINC Code

81732-0

Test Alias

PM/Scl-100 IgG
PM/Scl-100
PM1 Antibody
Polymyositis

Additional Information / Notes

N/A