Clinical Indications

Patient variability in the pharmacokinetics of posaconazole
supports quantitative monitoring of blood drug levels, particularly
due to its variable absorption. Monitoring trough levels of
posaconazole is suggested in patients with suboptimal nutritional
intake (and therefore requiring food and liquid nutritional
supplementation), or in patients with gastrointestinal disease such
as mucositis, diarrhea, vomiting or GVHD.
Monitoring trough levels of posaconazole is also suggested in
patients treated with other drugs that either induce or inhibit
CYP450 isoenzymes or that serve as substrates for these isoenzymes.
Results may be clinically useful to determine if current dosing
levels have achieved adequate therapeutic concentrations of
posaconazole.