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Test Code VZVSS Varicella Zoster Virus (VZV) Qualitative Real-time PCR (Skin swab)

Clinical Indications

VZV reactivation is commonly seen in
immunocompromised individuals. These patients are more likely to
have disseminated disease with extensive skin lesions, pneumonia,
hepatitis, or encephalitis. Proper management is dependent upon
early diagnosis; quantitative DNA
PCR is a rapid and sensitive tool useful
for detecting the virus, tracking the course of the infection, and
monitoring response to treatment.

Additional Test Codes

Epic Order Name: VZV PCR QUAL, SKIN
Sunquest Order Code: VZVSS
Epic Px Code: LAB2956

Specimen Collection Type

Sterile swab of site placed in viral transport media (M4-RT, M4,
or M5 media). Do not use calcium alginate swab or wood shafted
swab.

Minimum Collection Volume

N/A

Reference Range

Detected/Not Detected

Critical Value

N/A

Interpretation

The primers and probes used in this assay are specific for
VZV based on similarity search
algorithms. Additionally, no cross reactivity was detected when
tested against adenoviruses, BKV,
CMV, EBV,
HSV-1, HSV-2,
HHV-6 variant A, HHV-6 variant B, HHV-7,
HHV-8, JCV,
parvovirus B19, and SV-40.

Rejection Criteria

Specimens beyond their acceptable length of time from collection
as listed in the specimen stability, specimens other than those
listed. Do not use calcium alginate swab or wood shafted swab.

Specimen Availability for Add-on Testing

This test cannot be added on.

Specimen Stability

Refrigerated (preferred): 4 days
Frozen: 7 days
Ambient: 1 day

Day(s) Performed

Monday through Saturday

Performing Lab- Department

TUKHS-BH-Mail Outs

CPT Code

87798

LOINC Code

N/A

Test Alias

Herpes Zoster, Skin swab
VZV molecular detection, Skin swab
VZV PCR, Skin
swab

Additional Information / Notes

Turnaround time: Same day (within 8 – 12 hours from
receipt of specimen)
Note: This is a qualitative assay